Severe hypomagnesaemia in long-term users of proton-pump inhibitors
نویسندگان
چکیده
منابع مشابه
Hypomagnesaemia associated with long-term use of proton pump inhibitors
Hypomagnesaemia and associated hypocalcaemia and hypoparathyroidism have been increasingly recognised as rare long-term side-effects of proton pump inhibitors (PPIs). The PPIs may inhibit active magnesium (Mg) absorption by interfering with transcellular transient receptor potential melastatin-6 and -7 (TRPM 6 and 7) channels. More recent cell culture studies have suggested concomitant inhibiti...
متن کاملDoes long-term use of proton pump inhibitors cause hypomagnesaemia in Japanese outpatients?
AIM Hypomagnesaemia has been reported associated with long-term proton pump inhibitor (PPI) treatment. However, there have been no studies in Japanese patients. We therefore assessed the effects of long-term PPI use on serum magnesium concentrations in Japanese patients. METHODS Data from 481 outpatients who visited our centre in October and November 2011 were reviewed to determine their unde...
متن کاملHypomagnesaemia due to use of proton pump inhibitors--a review.
Magnesium homeostasis is essential for many intracellular processes and depends on the balance of intestinal absorption and renal excretion. Hypomagnesaemia may arise from various disorders. We review the literature on hypomagnesaemia due to the use of proton pump inhibitors, as illustrated by a case of a 76-year-old woman with muscle cramps and lethargy caused by hypomagnesaemia and hypocalcae...
متن کاملLong-term kidney outcomes among users of proton pump inhibitors without intervening acute kidney injury.
Proton pump inhibitor (PPI) use is associated with an increased risk of acute kidney injury (AKI), incident chronic kidney disease (CKD), and progression to end-stage renal disease (ESRD). PPI-associated CKD is presumed to be mediated by intervening AKI. However, whether PPI use is associated with an increased risk of chronic renal outcomes in the absence of intervening AKI is unknown. To evalu...
متن کاملA Patient on Long-Term Proton Pump Inhibitors Develops Sudden Seizures and Encephalopathy: An Unusual Presentation of Hypomagnesaemia
Objective. To present an unusual but known cause of hypomagnesaemia induced-hypocalcaemia in a chronic GORD patient with severe symptoms with a review of the current literature. Methods. Analysis of the clinical and laboratory findings of the patient and discussion of the multi-factorial nature of his disease and the underlying mechanisms. Results. Our patient described features of magnesium de...
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ژورنال
عنوان ژورنال: Clinical Endocrinology
سال: 2008
ISSN: 0300-0664,1365-2265
DOI: 10.1111/j.1365-2265.2008.03194.x